TRPA1 analgesia is mediated by kappa opioid receptors
Evangelia Semizoglou, Clive Gentry, Nisha Vastani, Cheryl L. Stucky, David A. Andersson, Stuart Bevan
This study shows TRPA1 inhibition enhances KOR activity in sensory neurons, leading to analgesia, and identifies TRP channel regulation of GPCR activity as a novel mechanism for peripherally mediated pain relief.
bioRxiv · Sep 1, 2022 · PreprintNeuroscience