Jing Yang

Assembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex

This study uses cryo-EM to reveal structural mechanisms of KMN complex assembly and phospho-regulation in budding yeast kinetochores.

Models for the architecture of the human inner kinetochore CCAN complex on centromeric α-satellite CENP-A nucleosome arrays

The paper determines cryo-EM structures of the CCAN complex bound to different DNA sequences to understand its architecture on centromeric α-satellite CENP-A nucleosome arrays.

Molecular mechanism of Mad2 conformational conversion promoted by the Mad2-interaction motif of Cdc20

This study elucidates how the Cdc20MIM induces Mad2 conformational conversion by transiently exposing a binding site and facilitating structural changes.

A comparative study of the cryo-EM structures of S. cerevisiae and human anaphase-promoting complex/cyclosome (APC/C)

This study compares cryo-EM structures of S. cerevisiae and human APC/C complexes, revealing conserved architectures and differences in regulatory mechanisms.

Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction

The paper describes the structure of the budding yeast outer kinetochore complexes and how phosphorylation regulates their stability during mitotic error correction.