Author

Soumyabrata Guha

Centre National de la Recherche ScientifiqueORCID 0000-0002-8996-6340Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:multiple species· 1

Frequent Co-Authors

Adeline AugereauiD· 3 shared Isabelle K. VilaiD· 3 shared Joanna ReiD· 3 shared Morgane ChemariniD· 3 shared Nadine LaguetteiD· 3 shared Yasmine Messaoud-NaceriD· 3 shared Clara TaffoniiD· 2 shared Hanane ChammaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Adeline AugereauORCID

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3 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedMar 24, 2026

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni…·Nadine Laguette

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

2 citations

humanproteomics

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ImmunologybioRxivPreprintNov 17, 2025

Regulation of lipid metabolism is a primordial function of STING

Soumyabrata Guha, Joanna Re, Morgane Chemarin…·Nadine Laguette

This study shows STING regulates lipid metabolism across species, independent of its role in antiviral immunity.

2 citations

multiple speciesexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedNov 7, 2025

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma, Soumyabrata Guha, Roger-Junior Eloiflin…·Nadine Laguette

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

7 citations

humanexperimental assay

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