Roger-Junior Eloiflin

This study identifies the RIG-I/MDA5-MAVS-IRF3 axis as the pathway sensing TONV infection and activating the IFN-I response to restrict viral replication.

This study evaluates strain-dependent differences in PPRV infection of APCs from three host species using in vitro models, finding differential permissiveness and viral persistence.

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

The paper adapts the SHERLOCK CRISPR-based detection tool for trypanosome species in pigs to improve AAT diagnostics and identify human-infectious trypanosome reservoirs.

This study compares immune responses in goats infected with high and low virulent PPRV strains, finding strain-specific differences in early inflammation and lymphocyte suppression.