Author

Isabelle K. Vila

Centre National de la Recherche ScientifiqueORCID 0000-0002-6834-5721Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Assay:imaging· 1

Frequent Co-Authors

Nadine LaguetteiD· 4 shared Yasmine Messaoud-NaceriD· 4 shared Adeline AugereauiD· 3 shared Joanna ReiD· 3 shared Joe McKellariD· 3 shared Karim MajzoubiD· 3 shared Morgane ChemariniD· 3 shared Soumyabrata GuhaiD· 3 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

Nadine LaguetteORCID

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4 papers

Recent·Most cited

ImmunologyThe Journal of Experimental MedicinePeer-reviewedMar 24, 2026

DNA-PK interacts with cyclic dinucleotides and inhibits type I Interferon responses

Isabelle K. Vila, Yasmine Messaoud-Nacer, Clara Taffoni…·Nadine Laguette

The paper identifies DNA-PKcs as a regulator of cyclic dinucleotide signaling, showing it interacts with CDN and modulates STING activation and antiviral responses.

2 citations

humanproteomics

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MicrobiologyCellPeer-reviewedMar 6, 2026

Deltaviruses spread through a viral Trojan Horse

Joe McKellar, Aurélien Fouillen, Sébastien Lyonnais…·Karim Majzoub

This study shows deltaviruses use helper virus particles as Trojan Horses for cell entry, revealing a new mode of viral transmission.

5 citationstop 1%

imagingmicroscopy & imaging analysis

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ImmunologybioRxivPreprintNov 17, 2025

Regulation of lipid metabolism is a primordial function of STING

Soumyabrata Guha, Joanna Re, Morgane Chemarin…·Nadine Laguette

This study shows STING regulates lipid metabolism across species, independent of its role in antiviral immunity.

2 citations

multiple speciesexperimental assay

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ImmunologyNature CommunicationsPeer-reviewedNov 7, 2025

The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling

Hanane Chamma, Soumyabrata Guha, Roger-Junior Eloiflin…·Nadine Laguette

This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.

7 citations

humanexperimental assay

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