Author

Daphne E.C. Boer

Leiden University Medical CenterORCID 0000-0003-3446-7795Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Alfred C.O. VertegaaliD· 2 shared Diana van den HeuveliD· 2 shared Martijn S. LuijsterburgiD· 2 shared Román González‐PrietoiD· 2 shared Alexander van OudenaardeniD· 1 shared Annelotte P. WondergemiD· 1 shared Brooke L. LatouriD· 1 shared Calvin Shun Yu LoiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersGenomics

Alfred C.O. VertegaalORCID

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2 papers

Recent·Most cited

THE NSL COMPLEX PROMOTES NEURAL DEVELOPMENT BY PREVENTING R-LOOP INDUCED REPLICATION STRESS

Jolanthe Lingeman, Diana van den Heuvel, Jeroen van den Berg, Jenny Kaur Singh, Rosanne van Hooijdonk, Wouter W. Wiegant, Daphne E.C. Boer, Calvin Shun Yu Lo, Ανδρέας Παναγόπουλος, Román González‐Prieto, Marnix Franken, Nikki Kolsters, Olivier G. de Jong, Alfred C.O. Vertegaal, Matthias Altmeyer, , Haico van Attikum

This study shows the NSL complex prevents R-loop induced replication stress during neural development, leading to developmental abnormalities when disrupted.

bioRxiv · Aug 22, 2025 · PreprintGenomics

ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

Yana van der Weegen, Klaas de Lint, Diana van den Heuvel, Yuka Nakazawa, Tycho E.T. Mevissen, Janne J. M. van Schie, Marta San Martín Alonso, Daphne E.C. Boer, Román González‐Prieto, Ishwarya Venkata Narayanan, Noud H.M. Klaassen, Annelotte P. Wondergem, Khashayar Roohollahi, Josephine C. Dorsman, Yuichiro Hara, , Martijn S. Luijsterburg

This study identifies ELOF1 as a factor that directs CRL4CSA to ubiquitylate RNAPII at K1268, facilitating TCR and protecting CSB-deficient cells from transcription-replication collisions.

Nature Cell Biology · Jun 1, 2021Peer-reviewedMolecular Biology