Mohammad R. Nikmaneshi

Immortalized smooth muscle cells enhance in vitro vasculogenesis

This study develops immortalized smooth muscle cells to support stable in vitro vasculogenesis, enabling long-term vascularized tumor models for functional studies and drug screening.

A Hybrid Multiscale Model for Predicting CAR-T Therapy Outcomes in SolidTumors

This paper develops a 3D tumor microenvironment model to predict CAR-T therapy outcomes in solid tumors, finding that collagen density and metabolic competition are key determinants of efficacy.

Overcoming impaired antigen presentation in tumor draining lymph nodes facilitates immunotherapy

This study shows that breast tumors impair antigen presentation in local lymph nodes, which can be overcome by delivering IL1β or adjuvants to distant lymph nodes, improving anti-cancer immune responses.

Optimizing Cancer Vaccinations Using a Physiologically Based Pharmacokinetic (PBPK) Model

This paper develops a PBPK model to optimize cancer vaccine design by simulating antigen transport and immune responses across organs.