This study identifies lamin B1 as a regulator of separase activity during mitosis, showing that lamin B1 depletion or overexpression disrupts chromosome separation and centrosome stability.

Nucleic Acids Research · Aug 15, 2026Peer-reviewedCell Biology

An evolutionarily conserved role for separase in the regulation of nuclear lamins

Francesca Cipressa, Gaëlle Pennarun, Giuseppe Bosso, Serena Rosignoli, Liliana Tullo, Nadia Schiralli, Claudia Di Dio, Chiara Borghi, Alessandro Paiardini, Giuseppe Esposito, Michael Lewis Goldberg, Pascale Bertrand, Giovanni Cenci

This study shows that separase interacts with nuclear lamins in Drosophila and humans, affecting nuclear organization and lamin levels, indicating an evolutionarily conserved role.

Cell Death Discovery · Oct 21, 2025Peer-reviewedGenetics

53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

Melissa Leriche, Clara Bonnet, Jagannath Jana, Gita Chhetri, Sabrina Mennour, Sylvain Martineau, Vincent Pennaneach, Didier Busso, Xavier Veaute, Pascale Bertrand, Sarah Lambert, Kumar Somyajit, Patricia Uguen, Stéphan Vagner

This study shows 53BP1 interacts with RNA primers from Okazaki fragments during DNA replication, supporting their processing and highlighting an RNA-protein interaction at replication forks.

Cell Reports · Nov 1, 2023Peer-reviewedMolecular Biology