Author

Clara Bonnet

Mount Sinai HospitalORCID 0000-0002-9197-485XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Daniel DurocheriD· 2 shared Frank SicheriiD· 2 shared Lisa HoegiD· 2 shared Alexander van OudenaardeniD· 1 shared Andrew N.J. TuttiD· 1 shared Anja GrothiD· 1 shared Anne‐Claude GingrasiD· 1 shared Antranik MavousianiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersMolecular Biology

Daniel DurocherORCID

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Mitotic single-stranded DNA suppression by DDIAS

Yibo Xue, Faisal Bin Rashed, Daniel Y.L. Mao, Kento T. Abe, Zhen‐Yuan Lin, Dragomir B. Krastev, Dheva Setiaputra, Lisa Hoeg, Clara Bonnet, Arun Kumar, Antranik Mavousian, Arussa Maan, Elizabeth J. Harvey-Jones, Stephen J. Pettitt, Andrew N.J. Tutt, , Daniel Durocher

The paper identifies DDIAS as a DNA-binding effector of the CIP2A-TOPBP1 complex that suppresses single-stranded DNA during mitosis, protecting genome integrity and interacting genetically with DNA polymerase.

Molecular Cell · Aug 24, 2026Peer-reviewedMolecular Biology

WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response

Rinskje B. Tjeerdsma, Timothy F. Ng, Maurits Roorda, Daniëlle Bianchi, Sora Yang, Clara Bonnet, Michael A. VanInsberghe, Marieke Everts, Femke J. Bakker, H. Rudolf de Boer, Nathalie Moatti, Nicole Hustedt, Jay Z. Yin, Lisa Hoeg, Matthew Leibovitch, , Marcel A.T.M. van Vugt

This study shows WEE1 inhibitors trigger the integrated stress response via GCN2 activation, leading to translational shutdown, which can be mitigated by low-dose or combination treatments.

Nature Communications · Nov 24, 2025Peer-reviewedCancer Biology

53BP1 interacts with the RNA primer from Okazaki fragments to support their processing during unperturbed DNA replication

Melissa Leriche, Clara Bonnet, Jagannath Jana, Gita Chhetri, Sabrina Mennour, Sylvain Martineau, Vincent Pennaneach, Didier Busso, Xavier Veaute, Pascale Bertrand, Sarah Lambert, Kumar Somyajit, Patricia Uguen, Stéphan Vagner

This study shows 53BP1 interacts with RNA primers from Okazaki fragments during DNA replication, supporting their processing and highlighting an RNA-protein interaction at replication forks.

Cell Reports · Nov 1, 2023Peer-reviewedMolecular Biology

BARD1 links histone H2A Lysine-15 ubiquitination to initiation of BRCA1-dependent homologous recombination

Jordan R. Becker, Clara Bonnet, Gillian Clifford, Anja Groth, Marcus D. Wilson, J. Ross Chapman

This study identifies BARD1's role in recruiting BRCA1 to DNA damage sites via H2AK15ub binding, linking it to HR and pathway choice.

bioRxiv · Jun 1, 2020 · PreprintMolecular Biology