Roy Lardenoije

This paper introduces a multimodal pipeline for spatiomolecular analysis of tissue samples, demonstrating its application in Alzheimer's disease and type 2 diabetes.

This paper develops two epigenetic clocks for rhesus macaques and finds that early life adversity, specifically infant maltreatment, is associated with epigenetic age acceleration.

This study uses spatial transcriptomics to show gene expression changes across brain regions in mice after auditory threat conditioning, revealing altered transcriptional connectivity involving steroidogenic factor 1.

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

This study identifies cell-type-specific epigenetic changes in TNXB in Alzheimer's disease using bulk and single-cell analyses of the dorsal raphe nucleus.

This study identifies similar transcriptional responses to acute and chronic alcohol drinking in mouse amygdala subnuclei, highlighting shared pathways and potential therapeutic targets for AUD.

The paper identifies an epigenetic signature in rhesus macaques linked to innate fear responses and shows its association with human acoustic startle responses.