Claudia Klengel

Stressor Identity Shapes Reactivity To Subsequent Stress

This study shows that different types of acute stressors affect future fear learning differently in mice, with shock and social defeat enhancing fear memory recall, while restraint stress does not.

Fine mapping of PTSD GWAS reveals a role for amygdala Foxp2 in regulation of fear and threat responses

This study fine-maps PTSD GWAS data with amygdala eQTLs and shows FOXP2 expression is linked to increased PTSD risk, with functional validation in mice and humans.

Spermidine alleviates depression via control of the stress response

This study shows that spermidine supplementation improves depression symptoms by enhancing autophagy and correcting polyamine imbalances in both humans and mice.

A novel epigenetic clock for rhesus macaques unveils an association between early life adversity and epigenetic age acceleration

This paper develops two epigenetic clocks for rhesus macaques and finds that early life adversity, specifically infant maltreatment, is associated with epigenetic age acceleration.

SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration

This study shows that SKA2-regulated hyperactive secretory autophagy contributes to neuroinflammation and neurodegeneration in Alzheimer's disease.

Cell-type specific induction of cyclo-oxygenase-2 in layer II/III prefrontal cortical neurons mediates stress-induced anxiety phenotypes in mice.

This study identifies Ptgs2 as a stress-induced gene in specific prefrontal cortical neurons that mediates anxiety-like behaviors in mice.

Genome-wide transcriptional profiling uncovers a similar oligodendrocyte-related transcriptional response to acute and chronic alcohol drinking in the amygdala

This study identifies similar transcriptional responses to acute and chronic alcohol drinking in mouse amygdala subnuclei, highlighting shared pathways and potential therapeutic targets for AUD.

Analysis of Genetically Regulated Gene Expression identifies a trauma type specific PTSD gene, SNRNP35

The paper identifies SNRNP35 as a trauma type-specific PTSD gene through analysis of genetically regulated gene expression in PTSD cases and controls.