LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson's disease model
Lucas Blasco-Agell, Meritxell Pons‐Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernández‐Carasa, Valentina Baruffi, Marta González-Sepúlveda, Yvonne Richaud‐Patín, Senda Jiménez‐Delgado, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, , Antonella Consiglio
LRRK2 G2019S iPSC-derived microglia exposed to neuromelanin, but not α-synuclein fibrils, reduce healthy dopaminergic neuron numbers in co-culture; ivermectin prevents this, and post-mortem midbrain supports it.
Communications Biology · Aug 12, 2025Peer-reviewedCell Biology✦ In-depth digest