Author

Sebastian Restrepo Cruz

Yale Cancer CenterORCID 0009-0005-1165-4282Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Barbara Ann BurtnessiD· 2 shared A. Mack Peters· 1 shared Allison MacMillan· 1 shared Ansley M. RocheiD· 1 shared Benjamin Schiff· 1 shared Cindy YangiD· 1 shared Craig DorrelliD· 1 shared Dejian ZhaoiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Barbara Ann BurtnessORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintNov 21, 2025

In vivo assessment of differential toxicity of cancer treatment drugs in Fanconi Anemia

Craig Dorrell, Sebastian Restrepo Cruz, Allison MacMillan…·Markus Grompe

The paper develops an in vivo mouse model to assess the differential toxicity of cancer drugs on Fanconi Anemia mutant hematopoietic cells and identifies drugs with neutral toxicity.

1 citation

mouseexperimental assay

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Cancer BiologybioRxivPreprintMay 28, 2025

AURKA inhibition amplifies DNA replication stress to foster WEE1 kinase dependency and synergistic antitumor effects with WEE1 inhibition in cancers

Jong Woo Lee, Jackie Shi, Julian Barrantes…·Barbara Ann Burtness

This study shows that AURKA inhibition increases DNA replication stress in TP53-mutated cancers, creating a dependency on WEE1 that can be exploited with combined AURKA and WEE1 inhibition to enhance antitumor effects.

DOI 10.1101/2025.05.28.656693

humanexperimental assay

𝕏 PostBluesky