Bernhard Küster

The study identifies the role of Clade IB ZmRALF2/3 in regulating cell wall integrity during maize pollen tube growth through interactions with receptor kinases, co-receptors, and cell wall proteins.

CurveCurator assesses and classifies dose-response curve significance using a recalibrated F-statistic and provides p-values and false discovery rates for improved analysis.

The paper provides a comprehensive proteomic map of 13 human brain regions using high-throughput mass spectrometry, highlighting region-specific protein expression patterns and markers.

This study identifies UHMK1 as a splicing regulatory kinase by showing its role in phosphorylation, alternative splicing, and cellular processes through integrated phosphoproteomics and RNA-seq analyses.

The paper introduces a web-based tool for cross-resource peptide spectrum comparison and visualization, with a focus on integration and retrieval from spectral databases.

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.

This study shows that stress enhances secretory autophagy via FKBP51, leading to increased MMP9 secretion and proBDNF cleavage to mature BDNF, linking stress adaptation to psychiatric disorders.

This paper introduces a method to generate high-quality DIA-MS libraries using peptide predictions and empirical refinement, demonstrating its effectiveness in non-model organisms and non-canonical databases.

MOGSA integrates multiple omics data to improve gene set analysis by combining features across data types and reducing noise, revealing molecular subtypes in bladder cancer.

The paper quantifies protein-to-mRNA (PTR) ratios across 29 human tissues and identifies sequence determinants influencing these ratios, finding many new post-transcriptional regulatory elements.

The paper creates a proteome and transcriptome atlas of 29 human tissues, revealing differences in mRNA-protein abundance and challenges in proteogenomics.