Itamar Lev

Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors

The paper shows that dysfunction in maternal scavenger cells disrupts systemic RNA homeostasis, leading to transgenerational germline tumors in C. elegans.

BarlowTrack: A Self-Supervised Framework for Zero-Shot Multi-Object Cell Tracking

This paper introduces BarlowTrack, a self-supervised cell tracking framework that achieves zero-shot accuracy across conditions and labs for neuronal time series in C. elegans.

An intrinsic neuronal manifold underlies brain-wide hierarchical organization of behavior in C. elegans

The paper identifies an intrinsic neuronal manifold in C. elegans that underlies brain-wide hierarchical organization of behavior by gating neuron activity during specific brain states.

Nucleus-Independent Transgenerational Small RNA Inheritance in C. elegans

This study shows that small RNAs can be inherited transgenerationally in C. elegans without nuclear factors or chromatin changes, mediated by ZNFX-1 and germ granules.

Transgenerational Regulation of Sexual Attractiveness in C. elegans Nematodes

The paper shows that inherited small RNAs in C. elegans regulate sexual attraction and outcrossing rates across generations, influencing population genetics under stress.

Germ Granules Functions are Memorized by Transgenerationally Inherited Small RNAs

The paper shows that transgenerational small RNA inheritance in C. elegans can occur independently of germ granules in some mutants, but depends on ancestral germ granule function and HRDE-1.

H3K9me3 is Required for Transgenerational Inheritance of Small RNAs that Target a Unique Subset of Newly Evolved Genes

The paper shows that H3K9me3 is not universally required for RNAi inheritance in C. elegans, but its role depends on the gene being silenced.

Inter-generational Consequences for Growing C. elegans in Liquid

This study shows that growing C. elegans in liquid media leads to intergenerational changes in size, which are not fully reversible and may involve epigenetic mechanisms.