Author

Uri Seroussi

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Molecular Biology· 3 Genetics· 2

Signature Assays, Organisms & Methods

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Organism:C. elegans· 5 Approach:experimental assay· 5 Research Focus:cell type annotation· 2 Research Focus:gene regulatory network inference· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:multiome· 1 Assay:proteomics· 1

Frequent Co-Authors

Julie M. ClaycombiD· 5 shared Amanda G. Charlesworth· 3 shared Aaron W ReinkeiD· 2 shared Adam E. Sundby· 2 shared Alexandra R. WillisiD· 2 shared Robert X. LaoiD· 2 shared Acadia L. GrimmeiD· 1 shared Anat NitzaniD· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersMolecular Biology

Julie M. ClaycombORCID

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5 papers

Recent·Most cited

The RNA-binding activity of the TRIM-NHL protein NHL-2 is essential for miRNA-mediated gene regulation

Nasim Saadat, Rhys N. Colson, Acadia L. Grimme, Uri Seroussi, Joshua W. Anderson, Julie M. Claycomb, Matthew C. J. Wilce, Katherine McJunkin, Jacqueline A. Wilce, Peter R. Boag

This study shows that NHL-2's RNA-binding activity is essential for miRNA-mediated gene regulation in C. elegans, linking it to translational repression and miRISC complex function.

bioRxiv · Feb 13, 2024 · PreprintGenetics

A Comprehensive Survey of C. elegans Argonaute Proteins Reveals Organism-wide Gene Regulatory Networks and Functions

Uri Seroussi, Andrew Lugowski, Lina Wadi, Robert X. Lao, Alexandra R. Willis, Winnie Zhao, Adam E. Sundby, Amanda G. Charlesworth, Aaron W Reinke, Julie M. Claycomb

The paper systematically analyzes all 19 AGO proteins in C. elegans to uncover gene regulatory networks and novel phenotypes associated with their loss.

eLife · Feb 15, 2023Peer-reviewedMolecular Biology

Two isoforms of the essential C. elegans Argonaute CSR-1 differentially regulate sperm and oocyte fertility

Amanda G. Charlesworth, Uri Seroussi, Nicolas J. Lehrbach, Mathias S. Renaud, Adam E. Sundby, Ruxandra I. Molnar, Robert X. Lao, Alexandra R. Willis, Jenna R. Woock, Matthew J. Aber, Annette J. Diao, Aaron W Reinke, Gary Ruvkun, Julie M. Claycomb

The paper identifies two CSR-1 isoforms in C. elegans and shows they have distinct roles in fertility and immunity.

Nucleic Acids Research · Jul 19, 2021Peer-reviewedMolecular Biology

P granules protect RNA interference genes from silencing by piRNAs

John Paul T. Ouyang, Andrew W. Folkmann, Lauren Bernard, Chih-Yung Lee, Uri Seroussi, Amanda G. Charlesworth, Julie M. Claycomb, Géraldine Seydoux

The paper shows that P granules in C. elegans germ cells prevent RNA interference genes from being silenced by piRNAs, maintaining their expression.

Developmental Cell · Aug 8, 2019Peer-reviewedMolecular Biology

Germ Granules Functions are Memorized by Transgenerationally Inherited Small RNAs

Itamar Lev, Itai Antoine Toker, Yael Mor, Anat Nitzan, Guy Weintraub, Olga Antonova, Ornit Bhonkar, Itay Ben Shushan, Uri Seroussi, Julie M. Claycomb, Sarit Anava, Hila Gingold, Ronen Zaidel‐Bar, Oded Rechavi

The paper shows that transgenerational small RNA inheritance in C. elegans can occur independently of germ granules in some mutants, but depends on ancestral germ granule function and HRDE-1.

Current Biology · Aug 1, 2019Peer-reviewedGenetics