Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury
Ermanno Malagola, Alessandro Vasciaveo, Yosuke Ochiai, Woosook Kim, Biyun Zheng, Luca Zanella, Alexander L.E. Wang, Moritz A. Middelhoff, Henrik Nienhüser, Lu Deng, Feijing Wu, Quin T. Waterbury, Bryana R. Belin, Jonathan S. LaBella, Leah B. Zamechek, , Timothy Cragin Wang
This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.
Cell · Jun 1, 2024Peer-reviewedDevelopmental Biology