Chandan Guha

TIGIT expression dictates the immunosuppressive reprogramming of myeloid cells in glioblastoma

This study shows TIGIT expression in myeloid cells of the GBM microenvironment promotes immunosuppression, and its knockdown enhances T cell function via NLRP3 signaling.

Longitudinal multimodal characterization of radiation dermatitis in the C57BL/6J mouse model

This study develops a longitudinal C57BL/6J mouse model of radiation dermatitis, revealing early molecular changes and distinct temporal signatures of inflammation, barrier dysfunction, and fibrosis.

Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency

This study shows that CARM1 loss in GSCs disrupts developmental programming, shifts lineage towards radial glia, and creates a dependency on NGFR/NTRK signaling, making them vulnerable to NTRK inhibitors.

FLASH proton reirradiation, with or without hypofractionation, mitigates chronic toxicity in the normal murine intestine, skin, and bone.

Isthmus progenitor cells contribute to homeostatic cellular turnover and support regeneration following intestinal injury

This study challenges the traditional model of intestinal stem cells by showing that Lgr5+ cells are not the sole stem cell compartment and that stemness exists in the isthmus region, contributing to homeostasis and regeneration.