Adam Parker Hill

Protocol-dependent cardiomyocyte states determine disease modelling capacity of human iPSCs

This study compares sixteen iPSC-CM differentiation protocols to identify how protocol-dependent cell states affect disease modeling capacity for cardiovascular conditions.

Robotic Handling Preserves Induced Pluripotent Stem Cell Derived Vascular Smooth Muscle Cells Differentiation using a Weekend-free, Automatable, Low-variability, Low-cost (WALL) Protocol

This paper develops an automated protocol for differentiating iPSC-derived vascular smooth muscle cells and shows that automation does not compromise cell quality or protein expression.

Independent derivations of the axis of arrhythmia for predicting drug-induced torsades de pointes

This paper derives the axis of arrhythmia independently from drug datasets and biophysical simulations, showing convergence in predicting pro-arrhythmic risk with high accuracy.

Evaluating the predictive accuracy of ion channel models using data from multiple experimental designs

The paper evaluates the predictive accuracy of IKr ion channel models using voltage-clamp data from multiple experimental protocols and identifies parameter heterogeneity across cells.

A range of voltage-clamp protocol designs for rapid capture of hERG kinetics

The paper introduces voltage-clamp protocols for efficiently capturing hERG ion channel kinetics to aid in modeling.

A calibrated functional patch clamp assay to enhance clinical variant interpretation in KCNH2-related long QT syndrome

This study uses a high-throughput patch-clamp assay to reclassify KCNH2 variants of uncertain significance, providing evidence for clinical interpretation.

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

The paper investigates the role of KCa1.1 in sinus node function and arrhythmia risk across species, finding conserved effects of its loss of function.