Author

Noël J.‐M. Raynal

Centre Hospitalier Universitaire Sainte-JustineORCID 0000-0002-4241-6800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Daniel SinnettiD· 2 shared Maxime CaroniD· 2 shared Serge McGrawiD· 2 shared Alexandra Langford‐AvelariD· 1 shared Anaïs DarracqiD· 1 shared Anthony LemieuxiD· 1 shared Antoine MéantiD· 1 shared Elizabeth ElderiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersCell Biology

Daniel SinnettORCID

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2 papers

Recent·Most cited

Cell BiologyNucleic Acids ResearchPeer-reviewedFeb 8, 2025

Rescuing DNMT1 Fails to Fully Reverse the Molecular and Functional Repercussions of Its Loss in Mouse Embryonic Stem Cells

Elizabeth Elder, Anthony Lemieux, Lisa‐Marie Legault…·Serge McGraw

This paper investigates whether rescuing DNMT1 activity can reverse its loss in mouse embryonic stem cells, finding only partial reversal with lasting effects on epigenetic landscapes and cellular function.

9 citations

mouseDNA methylation

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Cancer BiologybioRxivPreprintJan 23, 2025

Time-dependent chromatin maturation during 3D spheroid culture improves preclinical modeling of non-small cell lung cancer

Anaïs Darracq, Nicolas Sgarioto, Marielle Huot…·Noël J.‐M. Raynal

This study shows that 3D spheroid culture of NSCLC cells undergoes time-dependent chromatin and transcriptomic changes that improve drug response prediction and correlation with tumors.

DOI 10.1101/2025.01.23.634518

humanscRNA-seq

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