Johnathan G. Crandall

This study evolved Spathaspora passalidarum to produce ethanol from lignocellulosic hydrolysates by improving tolerance to inhibitors like acetic acid.

The paper identifies allelic variation in MAL33 as a driver of ecological adaptation in maltose metabolism among Saccharomyces eubayanus strains.

The paper investigates the relationship between gene family expansions and metabolic traits in yeasts, finding that keystone gene families drive multiple metabolic innovations.

This study shows that adjusting pH and using SAA pretreatment improves biofuel production from drought-switchgrass hydrolysates.

The paper investigates how specialization in yeast sugar transporters restricts evolutionary paths by analyzing sequence-function relationships and evolutionary history.

The paper shows that ploidy reduction in yeast populations evolved for maltose utilization is driven by an interaction between cell type and metabolism, with haploid-like transcriptional programs conferring fitness advantages.

The paper introduces a rapid, inexpensive protocol for mapping nucleosome positions in fungi and mammalian cells, validated across multiple species and compatible with high-throughput sequencing.

The paper shows Isw2 is a targeted nucleosome remodeler through interactions with sequence-specific factors, using conserved acidic residues in Itc1 to position nucleosomes precisely.

This paper develops and validates engineered chromatin remodeling proteins (E-ChRPs) that can reposition nucleosomes and arrays, and evict DNA-binding proteins, with versatile targeting options.