Katja Steiger

NIK stabilization reprograms the pancreas toward chronic pancreatitis and pancreatic lipomatosis

This study shows that NIK stabilization causes chronic pancreatitis and pancreatic lipomatosis via RelB-dependent non-canonical NF-κB signaling.

Loss of the Y chromosome drives basal identity and metastatic potential via epigenetic reprogramming in pancreatic cancer

This study identifies LOY as a driver of aggressive PDAC through epigenetic reprogramming, linking it to EMT and metastasis, and highlights its clinical relevance as a biomarker.

Prospective pan-cancer phosphoproteomics at clinical scale extends therapeutic options in precision oncology

This study uses pan-cancer phosphoproteomics to identify therapeutic targets and improve precision oncology by analyzing 1,998 tumor samples and developing new scores for kinase activity and immune response.

Distinct colorectal cancer genotypes shape microbial ecosystems and reveal stage-specific microbiota dependencies

This study shows that different colorectal cancer genotypes create distinct microbial ecosystems and that microbiota dependence decreases as tumors progress.

Modeling pancreatic cancer tumor stroma co-evolution in an in ovo model

This study uses an in ovo model to show that the CAM platform supports tumor-stroma coevolution in pancreatic cancer, preserving patient-specific features and enabling functional analysis of stromal interactions.

Modulation of intestinal bile acids influences colonic mucosal responses

This study examines how bile acid modulation affects colonic epithelial responses in mice and humans, finding altered cell populations and gene expression associated with DCA exposure.

Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries

This study integrates single-cell spatial transcriptomics with bulk and single-cell RNA sequencing to reveal the molecular heterogeneity and mechanisms of atherosclerotic carotid artery plaques.

c-Rel drives pancreatic cancer metastasis through Fibronectin-Integrin signaling-induced isolation stress resistance and EMT activation

This study identifies c-Rel as a driver of pancreatic cancer metastasis by promoting EMT, ECM remodeling, and resistance to isolation stress through fibronectin-integrin signaling.

Tissue-adapted Tregs harness inflammatory signals to promote intestinal repair from therapy-related injury

The paper shows that Treg cells use IFNγ and IL-10 to promote intestinal stem cell growth and repair after injury.

Latent plasticity of the human pancreas across development, health, and disease.

The paper constructs a single-cell multiomics atlas of the human pancreas across development, health, and T2D, identifying plastic cell states and lineage trajectories.

Susceptibility to inflammatory bowel diseases promotes invasive carcinomas in a murine model of ATF6-driven colon cancer

This study shows that IBD susceptibility increases the risk of ATF6-driven tumorigenesis in a murine model.

InSituPy -- A framework for histology-guided, multi-sample analysis of single-cell spatial transcriptomics data

InSituPy provides a framework for analyzing single-cell spatial transcriptomics data alongside histology and metadata across multiple samples.

Towards routine proteome profiling of FFPE tissue: Insights from a 1,200 case pan-cancer study

The paper profiles proteomes from 1,220 FFPE tumors across six cancers, identifies a new normalization method, and reports a comprehensive pan-cancer proteome resource.

KRas, in addition to Tp53 is a driver for early carcinogenesis and a molecular target in a mouse model of invasive gastro-esophageal adenocarcinoma

This study identifies KRAS mutation as a driver of invasive gastro-esophageal adenocarcinoma in a mouse model, showing its synergistic role with Tp53 or Rb1 loss and potential as a therapeutic target.

The Limits of Molecular Signatures for Pancreatic Ductal Adenocarcinoma Subtyping

This study evaluates three PDAC molecular signatures across eight datasets, finding inconsistent subtyping and low classification accuracy, suggesting technical biases and the need for multi-omic approaches.

A pancreas specific Ptf1a-driven Cre mouse line causes paternally transmitted germline recombination

The paper reports germline recombination in Ptf1a-driven Cre mouse lines when the Cre allele is paternally transmitted, emphasizing the need for genotyping and maternal transmission to avoid unintended recombination.

Single nucleus and in situ RNA sequencing reveals cell topographies in the human pancreas

The paper uses single nucleus and in situ RNA sequencing to create a comprehensive atlas of human pancreas cells, revealing cell topographies and differences between adult and neonatal pancreata.

A machine learning algorithm predicts molecular subtypes in pancreatic ductal adenocarcinoma with differential response to gemcitabine-based versus FOLFIRINOX chemotherapy

This paper develops a machine learning model to predict molecular subtypes of PDAC from radiomic features, showing differential chemotherapy response based on subtype.