Teresa Puthussery

The extreme diversity of retinal amacrine cells has deep evolutionary roots

The paper reconstructs the evolutionary origins of retinal amacrine cell diversity using transcriptomic data from 24 vertebrate species, identifying 42 orthologous cell types and suggesting a hybrid precursor origin.

Rod pathway blockade improves visual function in a mouse model of photoreceptor degeneration

The paper shows that blocking rod pathways in a mouse model of retinitis pigmentosa reduces aberrant activity and improves cone-mediated visual function.

Comparative transcriptomic insights into the evolutionary origin of the tetrapod double cone

The paper uses transcriptomic data from six vertebrate species to investigate the evolutionary origin of the tetrapod double cone, finding that both members originated from ancestral red cones and rods emerged before cone diversification.

Rod signals are routed through specific Off cone bipolar cells in primate retina

The paper shows that in primate retina, AII amacrine cells preferentially route rod signals to specific Off-cone bipolar cells, suggesting specialized neural pathways for night vision.