Tom Baden

This paper evaluates fluorescent nanodiamond phantoms as a robust benchmarking tool for spatial resolution in two- and three-photon microscopy, showing they better capture depth-dependent optical degradation than conventional bead phantoms.

The paper shows that On-Off coding in vertebrate vision is a latent, dynamically regulated computation rather than a fixed circuit feature, revealed through zebrafish and mouse studies.

This study measures the input-output relations of photoreceptors in zebrafish and finds functional heterogeneity in their response to visual stimuli.

The paper proposes a median eye origin for the vertebrate retina, explaining its unique circuitry through evolutionary repurposing of preexisting photoreceptor circuits.

The paper uses transcriptomic data from six vertebrate species to investigate the evolutionary origin of the tetrapod double cone, finding that both members originated from ancestral red cones and rods emerged before cone diversification.

This study shows zebrafish use competing ancestral cone systems for vision, challenging the idea that cones work together for visual behavior and suggesting that spectral interactions in water drove vertebrate visual circuit evolution.

The paper investigates functional recovery of regenerated cone photoreceptors in adult zebrafish retinas after light-induced injury, finding restored physiological circuit functionality within 3 months.

The paper identifies miR-2b-1 as a microRNA regulating embryonic movement in Drosophila by targeting the chloride channel gene Motor.

The paper identifies two rod bipolar cell types in zebrafish that are related to mammalian rod bipolar cells, suggesting the primary rod pathway evolved over 400 million years ago.

The paper shows that birds use a different retinal circuit strategy compared to mammals, with On- and Off-circuits encoding visual information in a correlated manner rather than as opposing channels.

This study investigates how amacrine cells in zebrafish retinas differentially balance colour and greyscale processing in central and peripheral regions through distinct inhibitory circuits.

The paper uses spectral responses of bipolar cells in zebrafish to infer integration rules in the inner retina, revealing six dominant spectral motifs and a new axis of spectral opponency.

The paper shows that UV-cones in larval zebrafish eyes have distinct synaptic transfer functions based on their location, using a combination of imaging and modeling techniques.

The paper measures optokinetic response gain in zebrafish larvae across their visual field using a spherical LED arena and finds anisotropic responses consistent with retinal photoreceptor densities.

The paper investigates motion sensing in mouse retinal bipolar cells, finding that some possess motion-sensitive receptive fields and transmit direction-specific signals to downstream neurons.

The paper shows that larval zebrafish have imbalanced On- and Off-responses to different light wavelengths, which may enhance their ability to detect object colorfulness and proximity.

The paper reveals how larval zebrafish retinal circuits process color by rotating spectral information into primary achromatic and chromatic axes at the first synapse, a strategy also used by fruit flies.

The paper introduces an open-source LED controller for spectrally arbitrary visual stimulation and optogenetics during 2-photon imaging, demonstrating its use in zebrafish and Drosophila experiments.

This study shows how four types of mouse retinal ganglion cells use different dendritic integration rules, influenced by both morphology and ion channel distribution.

The paper characterizes retinal ganglion cells (RGCs) in larval zebrafish, revealing UV-responsive RGCs and complex color opponency, suggesting a dual-achromatic visual strategy for prey capture and color vision.

This paper introduces a new two-photon microscopy technique that expands the 3D field of view while maintaining single-cell resolution, enabling more comprehensive neuronal activity imaging in multiple organisms.

This paper introduces a flexible spatial visual stimulator with arbitrary spectrum control for use in vision research, demonstrating its application in mouse and zebrafish models.

The paper shows UV-cones in larval zebrafish are tuned for UV-bright prey capture through regional boosts in detection efficiency and synaptic calcium baseline.

This study shows larval zebrafish use anisotropic retinal circuits to process color asymmetrically across visual space, matching natural scene statistics.

The paper presents a low-cost, open-source hyperspectral scanner for natural imaging above and under water, demonstrating its utility and creating an open database for hyperspectral datasets.

This study shows mouse horizontal cells process cone input locally, with dendritic Ca2+ signals reflecting cone opsin activation and chromatic preference, supporting local feedback shaping cone output.

Openspritzer is an open hardware system for delivering picolitre volumes with performance comparable to commercial systems, demonstrated in neurobiology applications.

The paper shows that balanced excitatory and inhibitory inputs in bipolar cells decorrelate visual feature representation in the mammalian inner retina.