Sean D. Colloms

The paper measures the topological linkage change during Xer recombination at the psi site of plasmid pSC101, finding a +4 change consistent with a specific reaction mechanism.

This paper introduces a high-throughput AFM-based pipeline using deep learning to trace DNA topology, revealing new insights into DNA structures and their interactions.

This paper reports structures of ΦC31 integrase in complexes with DNA recombination sites, elucidating the structural basis of its unidirectional recombination mechanism.

The paper attempts to identify the region on the coiled-coil domain of the Streptomyces phage OC31 integrase that interacts with its cognate RDF gp3, but faces technical challenges in characterizing mutants.

The paper uses mathematical modeling to analyze serine integrase-mediated DNA assembly and suggests strategies to improve efficiency and precision.

The paper characterizes genetic circuit components in E. coli to develop a biosensor for detecting Campylobacter jejuni using xylulose as a biomarker.