This paper introduces Brightness Demixing, a method for distinguishing multiple fluorophores in SMLM by using brightness instead of spectral separation, enabling multi-target imaging in 2D and 3D.

Nature Methods · Jun 5, 2026Peer-reviewedBiophysics

Dihydroxyhexanoic acid biosynthesis controls turgor in pathogenic fungi

Naoyoshi Kumakura, Takayuki Motoyama, Keisuke Miyazawa, Toshihiko Nogawa, Julien Pernier, Katsuma Yonehara, Mayuko Sato, Yumi Goto, Kaori Sakai, Nobuaki Ishihama, K. MATSUMORI, Pamela Gan, Kiminori Toyooka, Sandrine Lévêque‐Fort, Hiroyuki Koshino, , Ken Shirasu

This study identifies PKS2 and PBG13 as essential for forming a semipermeable cell wall in pathogenic fungi, enabling turgor pressure and pathogenicity.

Science · Feb 12, 2026Peer-reviewedPlant Biology

BIN1 genetic risk factor for Alzheimer is sufficient to induce early structural tract alterations in entorhinal cortex-dentate gyrus pathway and related hippocampal multi-scale impairments

Rachel Daudin, Damien Maréchal, R Golgolab, Q Wang, Y Abe, T. Tsurugizawa, Nathalie Bourg, Maxime Sartori, Yann Loe-Mie, Joanna Lipecka, Ida Chiara Guerrera, A McKenzie, Brigitte Potier, P. Dutar, Julia Viard, , Michel Simonneau

This paper shows that BIN1 overexpression in mice leads to early structural and functional impairments in hippocampal pathways associated with Alzheimer's disease, independent of A-beta changes.

bioRxiv · Mar 9, 2021 · PreprintNeuroscience