Author

Luke Hoberecht

GenentechORCID 0000-0002-9231-8977Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Jean‐Philippe FortiniD· 2 shared Aaron T. L. LuniD· 1 shared Andrew J. KuehiD· 1 shared Angus P. R. JohnstoniD· 1 shared Benjamin HaleyiD· 1 shared Christina KoenigiD· 1 shared Dan Fayle· 1 shared Emily J. LelliottiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersMolecular Biology

Jean‐Philippe FortinORCID

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2 papers

Recent·Most cited

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

Wei Jin, Yexuan Deng, John E. La Marca, Emily J. Lelliott, Sarah T. Diepstraten, Christina Koenig, Lin Tai, Valentina Snetkova, Kristel M. Dorighi, Luke Hoberecht, Millicent G. Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, , Marco J. Herold

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.

Nature Communications · Jan 30, 2025Peer-reviewedMolecular Biology

The crisprVerse: a comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies

Luke Hoberecht, Pirunthan Perampalam, Aaron T. L. Lun, Jean‐Philippe Fortin

The paper introduces crisprVerse, a Bioconductor ecosystem for designing and annotating CRISPR gRNAs across multiple technologies and nucleases.

Nature Communications · Nov 2, 2022Peer-reviewedBioinformatics