Author

Pirunthan Perampalam

Western University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Cancer Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:CRISPR screen· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

Frederick A. DickiD· 3 shared Aaron T. L. LuniD· 1 shared Arturo Bujarrabal-DuesoiD· 1 shared Björn SchumacheriD· 1 shared Chad Kelawan· 1 shared Daniel T. PassosiD· 1 shared David H. MeyeriD· 1 shared James I. MacDonald· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersCancer Biology

Frederick A. DickORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

WNT8B and -9B promote the survival and dissemination of dormant ovarian cancer cells

Komila Zakirova, Daniel T. Passos, Chad Kelawan, Michael V. Roes, Rizwan Tahir, Malcolm Hill, Seung J. Kim, Matthew J. Cecchini, Marco Mura, Trevor G. Shepherd, Pirunthan Perampalam, James I. MacDonald, Frederick A. Dick

This study identifies WNT8B and WNT9B as critical for ovarian cancer cell survival and dissemination during dormancy, showing their inhibition could improve treatment outcomes.

bioRxiv · Aug 11, 2026 · PreprintCancer Biology

The DREAM complex links somatic mutation, lifespan, and disease

Zane Koch, Shuvro Prokash Nandi, Kate Licon, Arturo Bujarrabal-Dueso, David H. Meyer, Safa Saeed, Pirunthan Perampalam, Frederick A. Dick, Björn Schumacher, Ludmil B. Alexandrov, Trey E. Ideker

This study shows that DREAM complex activity influences somatic mutation burden, lifespan, and age-related disease, with reduced activity linked to longer lifespan and lower disease risk.

bioRxiv · Sep 15, 2025 · PreprintBioinformatics

GO-CRISPR: a highly controlled workflow to discover gene essentiality in loss-of-function screens

Pirunthan Perampalam, James I. McDonald, Frederick A. Dick

GO-CRISPR improves loss-of-function CRISPR screens by integrating guide-only controls and TRACS software, identifying novel pathways in tumor dormancy.

PLoS ONE · Dec 18, 2024Peer-reviewedSystems Biology

The crisprVerse: a comprehensive Bioconductor ecosystem for the design of CRISPR guide RNAs across nucleases and technologies

Luke Hoberecht, Pirunthan Perampalam, Aaron T. L. Lun, Jean‐Philippe Fortin

The paper introduces crisprVerse, a Bioconductor ecosystem for designing and annotating CRISPR gRNAs across multiple technologies and nucleases.

Nature Communications · Nov 2, 2022Peer-reviewedBioinformatics