Author

Sarah T. Diepstraten

The University of MelbourneORCID 0000-0002-1946-5161Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:CRISPR screen· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

Andrew J. KuehiD· 2 shared Benjamin HaleyiD· 2 shared Christina KoenigiD· 2 shared Jean‐Philippe FortiniD· 2 shared John E. La MarcaiD· 2 shared Kristel M. DorighiiD· 2 shared Lauren Whelan· 2 shared Lin TaiiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Andrew J. KuehORCID

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Author profile →

3 papers

Recent·Most cited

γδ T cells modulate anti-tumor immunity in small cell lung cancer

Jin Ng, Yue You, Tina Z. Zhang, Jonas B. Hess, Sarah A. Best, Alex Caneborg, Marcel Schmiel, Sarah T. Diepstraten, Tim Spelman, Joshua I. Gray, Dale Ian Godfrey, Yin Wu, Richard W. Tothill, Casey J. A. Anttila, Tracey M. Baldwin, , Kate D. Sutherland

This study identifies γδ T cell infiltration in SCLC and shows their anti-tumor activity, suggesting they could be therapeutic targets.

Cancer Cell · Sep 18, 2026Peer-reviewedCancer Biology

A novel, high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo

Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts, Amy J. Heidersbach, Christina Koenig, Kristel M. Dorighi, Lin Tai, Andrew J. Kueh, Lauren Whelan, Catherine W.T. Chang, Felix Brown, Gemma L. Kelly, Jean‐Philippe Fortin, Benjamin Haley, John E. La Marca, Marco J. Herold

This paper introduces Partita, a high-density CRISPRa platform for comprehensive gene activation studies, demonstrating its utility in identifying cancer dependencies and resistance pathways in vitro and in vivo.

Science Advances · Sep 18, 2026Peer-reviewedCancer Biology

Advancing the genetic engineering toolbox by combining AsCas12a knock-in mice with ultra-compact screening

Wei Jin, Yexuan Deng, John E. La Marca, Emily J. Lelliott, Sarah T. Diepstraten, Christina Koenig, Lin Tai, Valentina Snetkova, Kristel M. Dorighi, Luke Hoberecht, Millicent G. Hedditch, Lauren Whelan, Geraldine Healey, Dan Fayle, Kieran Lau, , Marco J. Herold

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.

Nature Communications · Jan 30, 2025Peer-reviewedMolecular Biology