Emily J. Lelliott

This study identifies TAK1 as a cancer-intrinsic checkpoint that limits CD8+ T cell-mediated anti-cancer immunity by suppressing TNF and IFNγ-induced apoptosis, and shows that targeting TAK1 enhances anti-tumor responses.

The paper introduces an enAsCas12a mouse model and associated libraries for efficient gene editing and screening, identifying drug resistance genes and enabling simultaneous gene knockouts and activations.