Michal Judith Besser

A Lymphomimetic Synthetic Immune Niche, Consisting of CCL21 and ICAM1, Accelerates the Expansion of Potent CAR T-cells

This paper shows that a synthetic immune niche with CCL21 and ICAM1 boosts CAR T-cell expansion and potency, increasing cell yield and CAR T-cell frequency.

Context-dependent determinants of CRISPR-Cas9 editing efficiency revealed through cross-species endogenous editing analysis

The paper identifies context-dependent factors affecting CRISPR-Cas9 editing efficiency across species using endogenous editing data and shows that repair outcomes are conserved.

Differential effects of immobilized CCL21 and ICAM1 on TILs with distinct expansion properties

This study identifies markers distinguishing TIL expansion properties and develops SIN-based strategies to enhance expansion and activation of both low- and high-expanding TILs.