Decoupling T Cell Cytotoxicity: A CCL21+ICAM1-Based Synthetic Immune Niche Enhances Tumor Elimination by Accelerating Lytic Hit Delivery
Manish Kumar Gupta, Rawan Zoabi, Sofi Yado, Jörn Starruß, Benjamin Geiger, Haralampos Hatzikirou
This study identifies that a synthetic immune niche enhances T cell cytotoxicity by accelerating lytic hit delivery, not by increasing target encounters or conjugate stability.
BMC Cancer · Oct 15, 2026Peer-reviewedImmunology