Optic cup folding is driven by the geometry and tension of the Retinal Pigmented Epithelium (RPE) cells
Juan Aperador-Redondo, Estefanía Sanabria‐Reinoso, Javier Macho Rendón, Rocío Polvillo, Juan Ramón Martínez‐Morales, María Almuedo‐Castillo
The paper investigates how Wnt/β-catenin and YAP pathways regulate RPE cell geometry and tension during optic cup folding, showing their role in mechanical properties and nuclear signaling.
bioRxiv · Jul 3, 2026 · PreprintDevelopmental Biology