Juan Ramón Martínez‐Morales

Optic cup folding is driven by the geometry and tension of the Retinal Pigmented Epithelium (RPE) cells

The paper investigates how Wnt/β-catenin and YAP pathways regulate RPE cell geometry and tension during optic cup folding, showing their role in mechanical properties and nuclear signaling.

Zygotic genome activation is timed by the egg DNA-to-cytoplasm ratio across animals

The paper investigates ZGA timing across 61 animal species and finds that genome size to cytoplasm volume ratio predicts ZGA onset.

Single-cell multiomics identifies key nodes and cis-regulatory elements of the networks specifying the eye domains in zebrafish

The paper uses single-cell multiomics to identify key regulatory nodes and cis-regulatory elements in zebrafish eye development.

HUMAN SPINAL CORD ORGANOIDS REVEAL CELL INTERCALATION AS A CONSERVED MECHANISM FOR SECONDARY NEURULATION

The paper generates human spinal cord organoids that mimic in vivo development and identifies cell intercalation as a key mechanism for secondary neurulation.

Evolutionary conservation of embryonic DNA methylome remodelling in distantly related teleost species

The paper compares DNA methylation dynamics in medaka and zebrafish embryos, showing conserved remodelling patterns without global erasure, and identifies conserved non-canonical methylation reprogramming.

Comparative 3D genome analysis between neural retina and RPE reveals differential cis-regulatory interactions at retinal disease loci

The paper compares 3D genome structures between neural retina and RPE to identify tissue-specific cis-regulatory interactions at retinal disease loci.

Mutation of Vsx genes in zebrafish highlights the robustness of the retinal specification network.

The paper shows that vsx gene mutation in zebrafish causes bipolar cell depletion and visual impairment but maintains neural retina specification, highlighting genetic redundancy and network robustness.

Multi-omics profiling, in vitro and in vivo enhancer assays dissect the cis-regulatory mechanisms underlying North Carolina macular dystrophy, a retinal enhanceropathy

This study identifies cis-regulatory elements and non-coding variants associated with North Carolina macular dystrophy using multi-omics and enhancer assays.

A Yap-dependent transcriptional program directs cell migration for embryo axis assembly

This study shows that Yap proteins are essential for cell migration during embryo axis formation by regulating cytoskeletal organization and cell-ECM adhesion in medaka.

Trap-TRAP, a versatile tool for tissue-specific translatomics in zebrafish

The paper introduces trap-TRAP, a method to generate zebrafish transgenic lines for tissue-specific translatome analysis using TRAP combined with enhancer trap techniques.

Analysis of gene network bifurcation during optic cup morphogenesis in zebrafish

The paper analyzes gene network bifurcation during optic cup morphogenesis in zebrafish, identifying regulatory mechanisms and conserved TF recruitment sequences in RPE specification.

CRISPR-Cas13d induces efficient mRNA knock-down in animal embryos

This study demonstrates that CRISPR-Cas13d efficiently knocks down specific mRNAs in zebrafish, medaka, killifish, and mouse embryos, leading to significant transcript level reduction and embryonic phenotypes.

Genetic Developmental Timing Revealed by Inter-Species Transplantations in Fish

The paper uses inter-species blastula transplants in zebrafish and medaka to show that developmental modules like the retina follow autonomous genetic programs, decoupling from host timing.

Hierarchical stem cell topography splits growth and homeostatic functions in the fish gill

The paper identifies distinct homeostatic and growth adult stem cell populations in medaka gills, showing their spatial separation and functional specialization.