Author

Botao Liu

Southern University of Science and TechnologyORCID 0009-0006-6656-0221Unclaimed ORCID profile · follow to get notified of new preprints

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Botao Liu2 papers · University of Massachusetts Chan Medical School

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Heng ZhangiD· 1 shared Hui CheniD· 1 shared Jianbo LiiD· 1 shared Jiang DuiD· 1 shared Jing HuangiD· 1 shared Lihong DingiD· 1 shared Lijia MaiD· 1 shared Qingfeng Zhang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenomics

Heng ZhangORCID

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1 paper

Recent·Most cited

GenomicsNature Structural & Molecular BiologyPeer-reviewedMar 18, 2026

Spacer Extension Reconciles Specificity and Activity in High-Fidelity Cas9 Genome Editing

Rong Zheng, Zhike Lu, Rongwei Wei…·Lijia Ma

This study shows extending the spacer in SuperFi-Cas9 restores cleavage activity while maintaining specificity, offering a strategy to improve CRISPR efficiency and stability.

4 citationstop 2%

CRISPR screenexperimental assay

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