Nuclei sense complex tissue shape and direct intestinal stem cell fate
Kaustav Bera, Delaney L. McNally, Bruce E. Kirkpatrick, Nolan R. Petrich, F. Max Yavitt, Marilyne Coulombe, Michaela K. Quintero, Nathaniel P. Skillin, Alex Khang, Patrick S. McGrath, Linda C. Samuelson, Tanmay P. Lele, Peter J. Dempsey, Kristi S. Anseth
This study shows that nuclear mechanics influence intestinal stem cell differentiation by sensing tissue shape and modulating lamin-A levels.
bioRxiv · Oct 23, 2025 · PreprintBioengineering