Author

Tim Casey-Clyde

University of California, San FranciscoORCID 0000-0002-9281-4073Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

David Ronan RaleighiD· 2 shared Amy B. HeimbergeriD· 1 shared Angelo PeloneroiD· 1 shared Aparna BhaduriiD· 1 shared Arun PadmanabhaniD· 1 shared Calixto‐Hope G. LucasiD· 1 shared Camilla S. TengiD· 1 shared Courtney M. TamakiiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

David Ronan RaleighORCID

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2 papers

Recent·Most cited

IL-6 underlies microenvironment immunosuppression and resistance to therapy in glioblastoma

Jacob S. Young, Nam Woo Cho, Calixto‐Hope G. Lucas, Hinda Najem, Kanish Mirchia, William C. Chen, Courtney M. Tamaki, Harrshavasan Congivaram, Kyounghee Seo, Naomi Zakimi, Vikas Daggubati, Tim Casey-Clyde, Minh P. Nguyen, Zhenhong Chen, Joanna J. Phillips, , David Ronan Raleigh

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

Cancer Research · Apr 13, 2026Peer-reviewedCancer Biology

Eed controls craniofacial osteoblast differentiation and mesenchymal proliferation from the neural crest

Tim Casey-Clyde, Siyuan John Liu, Angelo Pelonero, Juan A. Cámara, Camilla S. Teng, Yoon‐Gu Jang, Harish N. Vasudevan, Arun Padmanabhan, Jeffrey Ohmann Bush, David Ronan Raleigh

This study shows that Eed is essential for craniofacial osteoblast differentiation and mesenchymal proliferation in neural crest cells, identified through mouse genetics, single-cell RNA sequencing, and epigenetic profiling.

eLife · Nov 19, 2025Peer-reviewedDevelopmental Biology