BiochemistryeLifePeer-reviewed
Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions.
Teresa Almeida, Eleanor Hargreaves, Tobias Zech, Igor Barsukov
The paper shows that the SxIP motif binds EBH with low affinity, but full interaction requires post-SxIP residues, leading to a nanomolar affinity and enhanced recruitment to microtubule plus ends.
2 citations