Igor Barsukov

This study identifies an internal PDZ-binding motif in Densin-180 that promotes SHANK scaffold remodelling through activity-dependent interactions.

The paper shows that the SxIP motif binds EBH with low affinity, but full interaction requires post-SxIP residues, leading to a nanomolar affinity and enhanced recruitment to microtubule plus ends.

This study investigates how the SPN-Ank domain of Shank3 regulates its localization and function in postsynaptic sites, showing its role in synaptic signaling and implications for autism-related mutations.

The paper identifies a SHANK3 missense mutation linked to ADHD-like phenotype and shows it disrupts protein interactions critical for neurodevelopmental function.