Thibault Mayor

Declining ribosome function limits oocyte longevity

This study shows that declining ribosome function contributes to oocyte aging by reducing translational capacity and causing developmental defects.

Chaperoning through time - defining DNAJA2 co-chaperone client selectivity via pulse-SILAC and BioID.

This study defines DNAJA2 co-chaperone client selectivity using pulse-SILAC and BioID to reveal distinct protein pools associated with DNAJA2 based on structural and physicochemical properties.

BAG6 and RNF126 promote the degradation of cytosolic misfolded proteins that contain buried degron motifs

The paper identifies BAG6 and RNF126 as key components in the degradation of cytosolic misfolded proteins containing buried degron motifs.

Recombinant Laccase Production Causes Alterations of the S. cerevisiae Proteome that are Dependent on the Strain Origins

This study measures proteome changes in S. cerevisiae during recombinant laccase expression and finds strain-specific responses linked to protein yield.

The co-chaperone DNAJA2 buffers proteasomal degradation of cytosolic proteins with missense mutations

The paper identifies cytosolic mutant proteins degraded by the proteasome and shows DNAJA2 stabilizes some mutants while being dispensable for wild-type proteins.

Mining Yeast Diversity Unveils Novel Targets for Improved Heterologous Laccase Production in Saccharomyces cerevisiae

The paper identifies yeast strains with enhanced recombinant laccase production and characterizes genetic factors contributing to this trait.

Analysis of protein levels and solubility in distinct brain regions reveals several elements of the protein homeostasis network that are impacted by aging

The paper analyzes protein levels and solubility in brain regions of aged mice, revealing age-related changes in proteostasis and inflammation markers.