Author

Mark Anthony Febbraio

Monash UniversityORCID 0000-0002-9296-4418Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

John W. ScottiD· 2 shared Alex Bernard AddinsalliD· 1 shared Anthony R. MeansiD· 1 shared Antonia L. CadelliD· 1 shared Ashley J. OvensiD· 1 shared Boaz H. NgiD· 1 shared Capucine Bianciotto· 1 shared Carl Hooper· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

John W. ScottORCID

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Author profile →

3 papers

Recent·Most cited

Gp130 Orchestrates a Bidirectional Neuron-Microglia Circuit for neuroprotection

Emily F. Willis, Samuel J. S. Stuart, Max Dierich, Laura F. Grice, Julia Ettich, Seung Jae Kim, Zhe Yang, Yi Xu, Carl Hooper, Capucine Bianciotto, Hong Wa Lao, Duy Pham, Quan Hoang Nguyen, Mark Anthony Febbraio, Frances Corrigan, , Jana Vukovic

This study identifies gp130 as a key receptor for a bidirectional neuron-microglia circuit that enhances neuroprotection after CNS injury.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Mechanism and cellular actions of the potent AMPK inhibitor BAY-3827

Conchita Fraguas Bringas, Mohd Syed Ahangar, Joyceline Cuenco, Hongling Liu, Alex Bernard Addinsall, Maria Lindahl, Ashley J. Ovens, Mark Anthony Febbraio, Marc Foretz, Olga Göransson, John W. Scott, Elton Zeqiraj, Kei Sakamoto

This paper describes the mechanism and cellular effects of the potent AMPK inhibitor BAY-3827, showing it selectively blocks AMPK-dependent functions.

Science Advances · Aug 22, 2025Peer-reviewedBiochemistry

PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins

Christopher R. Horne, Toby A. Dite, Samuel N. Young, Lucy J. Mather, Laura F. Dagley, Jared Lee Johnson, Tomer M. Yaron, Emily M. Huntsman, Leonard A. Daly, Dominic P. Byrne, Antonia L. Cadell, Boaz H. Ng, Jumana M. Yousef, Dylan H. Multari, Lianju Shen, , James M. Murphy

The paper identifies allosteric regulation of PSKH1 kinase activity by Ca2+ sensor proteins, showing both activation and suppression by different sensors.

Proceedings of the National Academy of Sciences · Feb 18, 2025Peer-reviewedBiochemistry