Author

Hendrik W. de Vries

University of GroningenORCID 0000-0002-9307-9015Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Erik Van der GiesseniD· 2 shared Patrick R. OnckiD· 2 shared Alessio FragassoiD· 1 shared Anders BarthiD· 1 shared Ashmiani van den BergiD· 1 shared Cees DekkeriD· 1 shared Eli O. van der SluisiD· 1 shared Harm Jan Beekhuis· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

Erik Van der GiessenORCID

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2 papers

Recent·Most cited

Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins

Hendrik W. de Vries, Anders Barth, Alessio Fragasso, Tegan A. Otto, Ashmiani van den Berg, Eli O. van der Sluis, Erik Van der Giessen, Liesbeth M. Veenhoff, Cees Dekker, Patrick R. Onck

This study designs and tests artificial FG-Nups to show that spacing and charge-to-hydrophobicity ratio affect Kap95 binding and transport selectivity through NPCs.

Nature Communications · Sep 28, 2026Peer-reviewedBiophysics

Kap-centric Nsp1-mediated nuclear transport at full amino-acid resolution

Maurice Dekker, Hendrik W. de Vries, Koen A. Wortelboer, Harm Jan Beekhuis, Maarten G.J.E. van Oosterhout, Erik Van der Giessen, Patrick R. Onck

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

Nature Communications · Dec 12, 2025Peer-reviewedBiophysics