Patrick R. Onck

Spatial control of karyopherin binding avidity within NPC mimics revealed by designer FG-Nucleoporins

This study designs and tests artificial FG-Nups to show that spacing and charge-to-hydrophobicity ratio affect Kap95 binding and transport selectivity through NPCs.

A two-bead-per-aminoacid coarse-grained MD model with hydrogen bonding (2BPA-HB) to probe DNAJB6b-mediated suppression of polyglutamine aggregation in Huntingtons disease

This paper develops a coarse-grained MD model to study DNAJB6b's role in suppressing polyglutamine aggregation in Huntington's disease, finding that DNAJB6b co-condensates with polyQ and inhibits amyloid formation.

Modeling disorder, secondary structure formation, and amyloid growth in FG-nucleoporins

This paper introduces a computational model to simulate the dual behavior of FG-nucleoporins between disordered and fibrillar states, showing their ability to form condensates and amyloid-like structures.

Kap-centric Nsp1-mediated nuclear transport at full amino-acid resolution

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

A coarse-grained MD model for disorder-to-order transitions in polyQ aggregation

This study develops a coarse-grained MD model to study polyQ aggregation mechanisms and finds that longer sequences aggregate faster and amyloid growth occurs primarily in the β-sheet direction.

The effect of dipeptide repeat proteins on FUS/TDP43-RNA condensation in C9orf72 ALS/FTD

This study investigates how dipeptide repeat proteins (DPRs) affect FUS/TDP43-RNA condensation in ALS/FTD, showing that R-DPRs disrupt condensates through cation-{pi} and electrostatic interactions.