Maurice Dekker

This paper develops a coarse-grained MD model to study DNAJB6b's role in suppressing polyglutamine aggregation in Huntington's disease, finding that DNAJB6b co-condensates with polyQ and inhibits amyloid formation.

This paper introduces a computational model to simulate the dual behavior of FG-nucleoporins between disordered and fibrillar states, showing their ability to form condensates and amyloid-like structures.

This study presents a modeling framework simulating nuclear transport at full amino-acid resolution, revealing the dynamic FG-meshwork and role of Nsp1 and NTRs in transport.

This study develops a coarse-grained MD model to study polyQ aggregation mechanisms and finds that longer sequences aggregate faster and amyloid growth occurs primarily in the β-sheet direction.