Ana Leonor Figueiredo

Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages

This study identifies two anti-ferroptosis pathways in iron-recycling macrophages that prevent cell death and maintain iron homeostasis, revealing a key role for ferroptosis in iron deficiency anemia.

Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance

This study shows that BVRA's catalytic activity is essential for malaria resistance and identifies a bilirubin concentration threshold needed for protection.

A Metabolite-Based Resistance Mechanism Against Malaria

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

Monocyte control of organismal energy homeostasis

This study shows that monocyte-derived macrophages regulate energy homeostasis by responding to iron metabolism dysregulation in parenchyma cells.

PFKFB4 control of Akt signaling is essential for premigratory and migratory neural crest formation.

This study identifies PFKFB4's role in regulating Akt signaling and glycolysis to control neural crest specification and migration.