Sharad Rastogi

Age-dependent disease tolerance to SARS-CoV-2 infection

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

Ferroptosis is a Physiologic Vulnerability of Iron-Recycling Macrophages

This study identifies two anti-ferroptosis pathways in iron-recycling macrophages that prevent cell death and maintain iron homeostasis, revealing a key role for ferroptosis in iron deficiency anemia.

Biliverdin Reductase Catalytic Activity Is Essential for Malaria Resistance

This study shows that BVRA's catalytic activity is essential for malaria resistance and identifies a bilirubin concentration threshold needed for protection.

A Metabolite-Based Resistance Mechanism Against Malaria

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

A bioenergetic basis for multiorgan dysfunction in sepsis

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.