Justin David Radolf

Comparison of a long-read amplicon sequencing approach to short-read amplicons for microbiome analysis

This paper compares StrainID long-read amplicon sequencing to short-read amplicons for microbiome analysis, showing similar performance overall but better phylogenetic diversity and taxonomic classification in saliva samples.

Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins

The paper analyzes sequence variability of BamA and FadL outer membrane proteins in 186 Treponema pallidum strains to identify evolutionary patterns and vaccine targets.

Immunodominant extracellular loops of Treponema pallidum FadL outer membrane proteins elicit antibodies with opsonic and growth-inhibitory activities

The paper identifies immunodominant extracellular loops (ECLs) from Treponema pallidum FadL proteins that elicit antibodies with opsonic and growth-inhibitory activities against syphilis-causing spirochetes.

Development and utilization of Treponema pallidum expressing green fluorescent protein to study spirochete-host interactions and antibody-mediated clearance: expanding the toolbox for syphilis research.

The paper develops a fluorescent Treponema pallidum strain to study spirochete-host interactions and antibody-mediated clearance, showing greater OM disruption with sera from rabbits infected with the Nichols strain.

Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres

The paper sequences Treponema pallidum from Chinese syphilis chancres using improved whole-genome sequencing methods without rabbit passage, revealing genetic diversity in China.