Author

David Šmajs

Masaryk UniversityORCID 0000-0002-4176-3464Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:variant calling· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Kay NieseltiD· 4 shared Petra PospíšilováiD· 3 shared Arlene C. SeñaiD· 2 shared Bin YangiD· 2 shared Heping ZhengiD· 2 shared Johannes KrauseiD· 2 shared Jonathan B. ParriD· 2 shared Justin David RadolfiD· 2 shared

Activity by Year

2016-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersMicrobiology

Kay NieseltORCID

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Author profile →

5 papers

Recent·Most cited

Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins

Everton Burlamarque Bettin, Farhang F. Aghakhanian, Christopher M. Hennelly, Wentao Chen, Timothy C. Davenport, Simon T. Hackl, André Alex Grassmann, Fabio Samir Vargas-Cely, Sebastián Silva, Jonny Alejandro García Luna, Lady G. Ramírez, Yinbo Jiang, Ligang Yang, Heping Zheng, Bin Yang, , Justin David Radolf

The paper analyzes sequence variability of BamA and FadL outer membrane proteins in 186 Treponema pallidum strains to identify evolutionary patterns and vaccine targets.

Journal of Bacteriology · Jul 14, 2025Peer-reviewedMicrobiology

A new typing scheme demonstrates high discriminatory power for Treponema pallidum subspecies

Marta Pla-Díaz, Lorenzo Giacani, Lauren C. Tantalo, Mahashweta Bose, Tara Brinck Reid, Christina M. Marra, David Šmajs, Petra Pospíšilová, Klára Janečková, Takuya Kawahata, Fumiya Banno, Kendra Vilfort, Weiping Cao, Allan Pillay, Angel Alberto Noda, , Fernando Gónzález‐Candelas

This paper introduces a new MLST scheme for Treponema pallidum subspecies with high discriminatory power, validated using global clinical samples and showing distinct genetic clusters.

bioRxiv · Jul 10, 2025 · PreprintMicrobiology

Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres

Wentao Chen, David Šmajs, Yongfei Hu, Wujian Ke, Petra Pospíšilová, Kelly L. Hawley, Melissa J. Caimano, Justin David Radolf, Arlene C. Seña, Joseph D. Tucker, Bin Yang, Jonathan J. Juliano, Heping Zheng, Jonathan B. Parr

The paper sequences Treponema pallidum from Chinese syphilis chancres using improved whole-genome sequencing methods without rabbit passage, revealing genetic diversity in China.

The Journal of Infectious Diseases · Jul 22, 2020Peer-reviewedGenomics

African Nonhuman Primates Are Infected With The Yaws Bacterium Treponema pallidum subsp. pertenue

Sascha Knauf, Jan F. Gogarten, Verena J. Schuenemann, Hélène M. De Nys, Ariane Düx, Michal Strouhal, Lenka Mikalová, Kirsten I. Bos, Roy Armstrong, Emmanuel K. Batamuzi, Idrissa S. Chuma, Bernard Davoust, Georges Diatta, Robert D. Fyumagwa, Reuben R. Kazwala, , Sébastien Calvignac-Spencer

The paper identifies naturally occurring simian Treponema pallidum subsp. pertenue strains in African nonhuman primates, showing genomic similarity to human TPE strains.

bioRxiv · May 10, 2017 · PreprintMicrobiology

Origin of modern syphilis and emergence of a contemporary pandemic cluster

Natasha Arora, Verena J. J Schuenemann, Günter Jäger, Alexander Peltzer, Alexander Seitz, Alexander Herbig, Michal Strouhal, Linda Grillová, Leonor Sánchez-Busó, Denise Kühnert, Kirsten I. I Bos, Leyla Rivero Rivero Davis, Lenka Mikalová, Sylvia Bruisten, Peter Komericki, , Homayoun C. C Bagheri

This study analyzes the genetic patterns of modern syphilis strains and identifies a globally dominant pandemic cluster with azithromycin resistance.

Nature Microbiology · Dec 5, 2016Peer-reviewedMicrobiology