This study analyzes Treponema pallidum strains in Buenos Aires, Argentina, using whole genome sequencing and tprK locus analysis to understand transmission dynamics and lineage-specific diversity.

bioRxiv · Apr 3, 2026 · PreprintMicrobiology

Sequence variability of BamA and FadL candidate vaccinogens suggests divergent evolutionary paths of Treponema pallidum outer membrane proteins

Everton Burlamarque Bettin, Farhang F. Aghakhanian, Christopher M. Hennelly, Wentao Chen, Timothy C. Davenport, Simon T. Hackl, André Alex Grassmann, Fabio Samir Vargas-Cely, Sebastián Silva, Jonny Alejandro García Luna, Lady G. Ramírez, Yinbo Jiang, Ligang Yang, Heping Zheng, Bin Yang, , Justin David Radolf

The paper analyzes sequence variability of BamA and FadL outer membrane proteins in 186 Treponema pallidum strains to identify evolutionary patterns and vaccine targets.

Journal of Bacteriology · Jul 14, 2025Peer-reviewedMicrobiology

Analysis of Treponema pallidum strains from China using improved methods for whole-genome sequencing from primary syphilis chancres

Wentao Chen, David Šmajs, Yongfei Hu, Wujian Ke, Petra Pospíšilová, Kelly L. Hawley, Melissa J. Caimano, Justin David Radolf, Arlene C. Seña, Joseph D. Tucker, Bin Yang, Jonathan J. Juliano, Heping Zheng, Jonathan B. Parr

The paper sequences Treponema pallidum from Chinese syphilis chancres using improved whole-genome sequencing methods without rabbit passage, revealing genetic diversity in China.

The Journal of Infectious Diseases · Jul 22, 2020Peer-reviewedGenomics