Andre J. W. van der Kouwe

High-resolution postmortem MRI of the human infant brain: cortical reconstruction and anatomical parcellation

This paper introduces a computational framework for automated anatomical segmentation and cortical reconstruction in high-resolution postmortem infant MRI, showing improved performance across diverse datasets.

The Infant Brainstem - A Multimodal Multiscale Postmortem Imaging Pipeline

This paper introduces a postmortem imaging pipeline for infant brainstem analysis, combining multiple modalities to overcome MRI limitations and enable high-resolution 3D visualization.

Spatial Image Gradient Estimation from the Diffusion MRI Profile

This paper estimates spatial image gradients from diffusion MRI signals by modeling relaxation-time properties, showing significant correlation with gold-standard gradients across multiple datasets.

Using short-read 16S rRNA sequencing of multiple variable regions to generate high-quality results to a species level.

This paper evaluates using short-read 16S rRNA sequencing of multiple variable regions to achieve species-level resolution and assesses sample collection impacts on results.

Imaging of developing human brains with ex vivo PSOCT and dMRI

This study uses PSOCT and ex vivo dMRI to image developing human brains, showing PSOCT's ability to quantify myelination and fiber orientation with micrometer resolution.

Distinct alterations in white matter properties and organization related to maternal treatment initiation in neonates exposed to HIV but uninfected

The paper examines how the timing of maternal ART initiation affects white matter integrity and organization in HIV-exposed uninfected neonates using DTI and graph theory.

Segmentation of supragranular and infragranular layers in ultra-high resolution 7T ex vivo MRI of the human cerebral cortex

This paper introduces a semi-supervised segmentation model for identifying supragranular and infragranular layers in human cerebral cortex MRI scans with high precision.

Sustaining wakefulness: Brainstem connectivity in human consciousness

The paper maps brainstem connections sustaining wakefulness using ex vivo diffusion MRI, immunohistochemistry, and in vivo 7 Tesla functional MRI.

Using synthetic MR images for field map-less distortion correction

This paper introduces Synth, a field map-less distortion correction method for fMRI data, showing comparable or better performance than field map-based approaches in pediatric and adult datasets.

A multimodal imaging and analysis pipeline for creating a cellular census of the human cerebral cortex

The paper develops an imaging pipeline to create a cell census of the human cerebral cortex using MRI, immunohistochemistry, and light-sheet fluorescence microscopy.

Tracing cortical circuits in humans and non-human primates from high resolution connectomic, transcriptomic, and temporal dimensions

The paper integrates transcriptional and connectomic data across temporal dimensions to trace the evolution of frontal cortex circuits in humans and non-human primates, finding conserved features across species.

Tractography-Pathology Correlations in Traumatic Brain Injury: A TRACK-TBI Study

This study uses ex vivo diffusion MRI and histopathology to correlate tract disruptions with axonal injury in a TBI patient.

Dynamic Brain-Body Coupling of Breath-by-Breath O2-CO2 Exchange Ratio with Resting State Cerebral Hemodynamic Fluctuations

The paper investigates the relationship between respiratory gas exchange metrics and cerebral hemodynamic fluctuations during spontaneous breathing, finding strong coupling between breath-by-breath O2-CO2 exchange ratio and low frequency CHF.

Brain wiring and supragranular-enriched genes linked to protracted human frontal cortex development.

The paper links protracted human frontal cortex development to expanded cortico-cortical projections and supragranular gene expression, using RNA sequencing and diffusion MR tractography.

Cerebrovascular reactivity assessment with O2-CO2 exchange ratio under brief breath hold challenge

The paper assesses cerebrovascular reactivity using the O2-CO2 exchange ratio during breath hold challenges and finds it better correlates with CBF changes than individual PCO2 or PO2 changes.

Correction of respiratory artifacts in MRI head motion estimates

This paper develops a band-stop filter to correct respiratory artifacts in MRI motion estimates, improving data quality and demonstrating real-time implementation.

7 Tesla MRI of the ex vivo human brain at 100 micron resolution

The paper presents an ultra-high resolution MRI dataset of an ex vivo human brain and provides it in both native and stereotactic spaces for research and educational use.

Image processing and analysis methods for the Adolescent Brain Cognitive Development Study

The paper describes neuroimaging processing methods for the ABCD Study to extract brain phenotypes from multimodal imaging data.